Biological Activity
Partial agonist of α7 nAChR. Improves mnemonic function in aged mice for the treatment of aging-related memory disturbances. Displays more efficient memory-enhancing effects than memantine (Cat. No. 0773) in Alzheimer's disease mouse models.
Technical Data
| M. Wt | 418.07 |
| Formula | C14H13BrINO |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 304679-75-2 |
| PubChem ID | 9888248 |
| InChI Key | LERUHBBUGAOYOD-UHFFFAOYSA-M |
| Smiles | BrC1=CC=C(C(CC2=[N+](C)C=CC=C2)=O)C=C1.[I-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.81 | 100 | |
| water | 4.18 | 10mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 418.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.39 mL | 11.96 mL | 23.92 mL |
| 5 mM | 0.48 mL | 2.39 mL | 4.78 mL |
| 10 mM | 0.24 mL | 1.2 mL | 2.39 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Lagostena et al (2008) The partial α7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus. Neuropharmacology 54 676 PMID: 18187166
Marighetto et al (2008) Comparative effects of the α7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice. Psychopharmacology. 197 499 PMID: 18265960
Beracochea et al (2008) Improvement of contextual memory by S 24795 in aged mice: comparison with memantine. Psychopharmacology 196 555 PMID: 18034231
Keywords: S 24795, supplier, S24795, partial, agonist, a7, nAChR, nicotinic, acetylcholine, receptor, α7, agonists, Nicotinic, (a7), Receptors, Nicotinic, (a7), Receptors, Tocris Bioscience
