Biological Activity
Potent neuropeptide Y (NPY) Y5 receptor antagonist (IC50 values are 5.4, > 1000, > 10 000 and > 10 000 nM at Y5, Y1, Y2 and Y4 receptors respectively) that displays no affinity for a wide range of other receptors. Does not produce a conditioned taste aversion, suppress sodium appetite or cause pica in rats. Significantly inhibits NPY-induced feeding but not through blockade of Y5 receptors.
Technical Data
| M. Wt | 528.5 |
| Formula | C22H23F3N4O6S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 263849-50-9 |
| PubChem ID | 10029880 |
| InChI Key | BRMJFKLHWFZWOQ-KOMQPUFPSA-N |
| Smiles | O=S(NC[C@H]1CC[C@H]([C@@](NNC(C3=CC=CC=C3)=O)=O)CC1)(C2=CC=C(C(F)(F)F)C=C2[N+]([O-])=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.85 | 100 | |
| ethanol | 52.85 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 528.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.89 mL | 9.46 mL | 18.92 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.78 mL |
| 10 mM | 0.19 mL | 0.95 mL | 1.89 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Beauverger et al (2005) Functional characterization of human neuropeptide Y receptor subtype 5 specific antagonists using a luciferase reporter gene assay. Cell.Signal. 17 489 PMID: 15601626
Della-Zuana et al (2004) A potent and selective NPY Y5 antagonist reduces food intake but not through blockade of the NPY Y5 receptor. Int.J.Obes. 28 628 PMID:
Kamiji and Inui (2007) Neuropeptide Y receptor selective ligands in the treatment of obesity. 28 664 PMID:
Keywords: S 25585, supplier, Potent, selective, NPY, Y5, antagonists, neuropeptide, Receptors, S25585, neuropeptides, NPY, Receptors, NPY, Receptors, Tocris Bioscience
