Tocris/SAG/4366/1/1毫克-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/SAG/4366/1/1毫克

Tocris/SAG/4366/1/1毫克

商品编号： 4366/1

品牌： Tocris Bioscience

市场价： ¥3100.00

美元价： 1860.00

产地：美国(厂家直采)

公司：

产品分类：受体

公司分类： Receptors

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:PotentSmoothenedreceptoragoNIST;activatestheHedgehogsignalingpathway

ChemicalName:3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentSmoothened(Smo)receptoragonist(K_d=59nM);antagonizesCyclopamineactionattheSmoreceptor.PotentlyactivatestheHedgehogsignalingpathwayinShh-light2cells(EC₅₀~3nM).InducespathwayactivationindependentlyofPtchproteins.PutativeinhibitorofacellularcomponentrequiredforHedgehogsignaling.EnhancesneuronaldifferentiationofiPSCsintodopaminergicneurons.

TechnicalData

M.Wt	490.06
Formula	C₂₈H₂₈ClN₃OS
Storage	Storeat-20°C
Purity	≥99%(HPLC)
CASNumber	912545-86-9
PubChemID	5284330
InChIKey	VFSUUTYAEQOIMW-UHFFFAOYSA-N
Smiles	ClC2=C(C(N([C@H]4CC[C@H](NC)CC4)CC3=CC=CC(C5=CC=NC=C5)=C3)=O)SC1=CC=CC=C12

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	1eq.HCl	24.5	50
	DMSO	49.01	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight490.06.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.04mL	10.2mL	20.41mL
5mM	0.41mL	2.04mL	4.08mL
10mM	0.2mL	1.02mL	2.04mL
50mM	0.04mL	0.2mL	0.41mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

TechnicalData

SolubilityData

PreparingStockSolutions

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