BiologicalActivity
Ahighlyselective,potentandcell-permeableinhibitorofp38MAPkinase.BindswithintheATPpocketoftheactivekinase(Kd=38nM,asmeasuredinrecombinanthumanp38),andselectivelyinhibitsthep38αandβisoforms(IC50=50and100nMatSAPK2a/p38andSAPK2b/p38β2respectively).PromotesstABIlityofnaivehumanpluripotentstemcellsinculture.AlsoavailableaspartoftheMAPKInhibitorTocriset™.
LicensingInformation
SoldwiththepermissionofGlaxoSmithKline
CompoundLibraries
SB202190isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 331.35 |
| Formula | C20H14N3OF |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 152121-30-7 |
| PubChemID | 16759148 |
| InChIKey | YKRNPHOBDOUQTG-UHFFFAOYSA-N |
| Smiles | OC1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=NC=C1)C1=CC=C(F)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto100mMinDMSO |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight331.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.02mL | 15.09mL | 30.18mL |
| 5mM | 0.6mL | 3.02mL | 6.04mL |
| 10mM | 0.3mL | 1.51mL | 3.02mL |
| 50mM | 0.06mL | 0.3mL | 0.6mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
本网站将在规定时间内给予删除等相关处理。
