Biological Activity
Potent 5-HT4 receptor antagonist with high affinity for human atrial 5-HT4 receptors.
Licensing Information
Sold with the permission of GlaxoSmithKline
Technical Data
| M. Wt | 308.81 |
| Formula | C16H20N2O2.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 207572-69-8 |
| PubChem ID | 9926639 |
| InChI Key | LYMBEMCUJNDSBZ-UHFFFAOYSA-N |
| Smiles | Cl.O=C(OCCN1CCCCC1)C1=CNC2=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 308.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.24 mL | 16.19 mL | 32.38 mL |
| 5 mM | 0.65 mL | 3.24 mL | 6.48 mL |
| 10 mM | 0.32 mL | 1.62 mL | 3.24 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.65 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
McLean and Coupar (1995) 5-HT4 receptor antagonist affinities of SB207710, SB205008 and SB 203186 in the human colon, rat oesophagus and guinea-pig ileum peristaltic reflex. Naunyn Schmiedebergs Arch.Pharmacol. 352 132 PMID: 747435
Midhurst and Kaumann et al (1993) Characterisation of 5-HT4 receptor mediating tachycardia in piglet isolated right atrium. Br.J.Pharmacol. 110 1023 PMID: 8298790
Parker et al (1995) Blockade of human and porcine myocardial 5-HT4 receptors by SB 203186. Naunyn Schmiedebergs Arch.Pharmacol. 353 28 PMID: 8750913
Keywords: SB 203186 hydrochloride, supplier, 5-HT4, antagonists, Serotonin, Receptors, 5-Hydroxytryptamine, 5-HT, SB203186, hydrochloride, GlaxoSmithKline, GSK, 5-HT4, Receptors, 5-HT4, Receptors, Tocris Bioscience
