BiologicalActivity
Selectiveinhibitorofp38MAPK(IC50valuesare50and500nMforSAPK2a/p38andSAPK2b/p38β2respectively).Displays100-500-foldselectivityoverLCK,GSK-3βandPKBα.ShowntoinhibitIL-2-inducedTcellproliferation,cyclooxygenase-1and-2,andthromboxanesynthase.EnhancesclonalgrowthofskinepithelialProgenitorcells;stimulatesneuralstemcell(NSC)proliferation.Essentialcomponentofmediumformaintainingstemcellsinnaivepluripotentstate.PartoftheMAPKCascadeInhibitorTocriset™andMAPKInhibitorTocriset™.Water-solublesaltSB203580hydrochloride(Cat.No.1402)alsoavailable.
LicensingInformation
SoldwiththepermissionofGlaxoSmithKline
CompoundLibraries
SB203580isalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 377.44 |
| Formula | C21H16FN3OS |
| Storage | Desiccateat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 152121-47-6 |
| PubChemID | 176155 |
| InChIKey | CDMGBJANTYXAIV-UHFFFAOYSA-N |
| Smiles | CS(=O)C1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=NC=C1)C1=CC=C(F)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 37.74 | 100 | |
| DMSO | 9.44 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight377.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.65mL | 13.25mL | 26.49mL |
| 5mM | 0.53mL | 2.65mL | 5.3mL |
| 10mM | 0.26mL | 1.32mL | 2.65mL |
| 50mM | 0.05mL | 0.26mL | 0.53mL |
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