Biological Activity
GABAA receptor modulator; slows current decay. Potentiates α6, α3 and α5-subunit-containing receptors (EC50 values are 280, 695 and 730 nM respectively). Displays little effect on receptors containing α1 or α2 subunits.
Compound Libraries
SB 205384 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 330.4 |
| Formula | C17H18N2O3S |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 160296-13-9 |
| PubChem ID | 197690 |
| InChI Key | JDTZAGLGBRRCJT-UHFFFAOYSA-N |
| Smiles | CC#CCOC(=O)C1=C(C)N=C2SC3=C(CCC(O)C3)C2=C1N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 33.04 | 100 | |
| DMSO | 16.52 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 330.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.03 mL | 15.13 mL | 30.27 mL |
| 5 mM | 0.61 mL | 3.03 mL | 6.05 mL |
| 10 mM | 0.3 mL | 1.51 mL | 3.03 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.61 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Meadows et al (1997) Effect of SB-205384 on the decay of GABA-activated chloride currents in granule cells cultured from rat cerebellum. Br.J.Pharmacol. 121 1334 PMID: 9257911
Meadows et al (1998) SB-205384: a GABAA receptor modulator with novel mechanism of action that shows subunit selectivity. Br.J.Pharmacol. 123 1253 PMID: 9559912
Hutcheon et al (2000) Developmental change in GABAA receptor desensitization kinetics and its role in synapse function in rat cortical neurons. J.Physiol. 522 3 PMID: 10618148
Heidelberg et al (2013) SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with 347 235 PMID: 23902941
Keywords: SB 205384, supplier, GABAA, receptor, modulators, slows, current, decay, Receptors, SB205384, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience
