Biological Activity
Potent and selective CCR3 antagonist (IC50 = 39 nM). Displays 250-fold selectivity for CCR3 over other chemokine receptors, including CXCR1, CXCR2, CCR1 and CCR7 (IC50 >27 μM). Inhibits calcium mobilization induced by MCP-4, eotaxin-2 and eotaxin in RBL-2H3 cells transfected with CCR3 (IC50 values are 80, 90 and 210 nM respectively).
Compound Libraries
SB 297006 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 342.35 |
| Formula | C18H18N2O5 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 58816-69-6 |
| PubChem ID | 9840971 |
| InChI Key | BEZXGSZPWXRHIN-INIZCTEOSA-N |
| Smiles | O=C(C2=CC=CC=C2)N[C@H](C(OCC)=O)CC1=CC=C([N+]([O-])=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.23 | 100 | |
| ethanol | 6.85 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 342.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.92 mL | 14.6 mL | 29.21 mL |
| 5 mM | 0.58 mL | 2.92 mL | 5.84 mL |
| 10 mM | 0.29 mL | 1.46 mL | 2.92 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Yoshimoto and Hansch (1976) Quantitative structure-activity relationships of D- and L-N-actyl-alpha-aminoamide ligands binding to chymotrypsin. On the problem of combined treatment of stereoisomers. J.Org.Chem. 41 2269 PMID: 932854
White et al (2000) Identification of a potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. J.Biol.Chem. 275 36626 PMID: 10969084
Keywords: SB 297006, supplier, SB297006, ccr3, chemokines, receptors, antagonists, selective, potent, Rantes, Chemokine, CC, Receptors, Chemokine, CC, Receptors, Tocris Bioscience
