BiologicalActivity
PotentandselectiveCCR3antagonist(IC50=4nM).Displays>2500-foldselectivityoverC5aR,LTD4,CCR7,CXCR1andCXCR2receptors.Inhibitseotaxin-,eotaxin-2-andMCP-4-inducedCa2+mobilization(IC50valuesare38,35and20nMrespectively)andinhibitseotaxin-,eotaxin-2-andMCP-4-inducedeosinophilchemotaxiswithsimilarpotencies.
CompoundLibraries
SB328437isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 378.38 |
Formula | C21H18N2O5 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 247580-43-4 |
PubChemID | 10474776 |
InChIKey | VMFGCGRAIBLAFY-IBGZPJMESA-N |
Smiles | O=C(C2=CC=CC3=C2C=CC=C3)N[C@H](C(OC)=O)CC1=CC=C([N+]([O-])=O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 37.84 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight378.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.64mL | 13.21mL | 26.43mL |
5mM | 0.53mL | 2.64mL | 5.29mL |
10mM | 0.26mL | 1.32mL | 2.64mL |
50mM | 0.05mL | 0.26mL | 0.53mL |