Biological Activity
Potent CXCR2 antagonist (IC50 = 7.7 nM). Exhibits 285-fold selectivity for CXCR2 over CXCR1. Reduces leukocyte numbers in synovial fluid in acute and chronic rabbit arthritis models. Also reduces synovial fluid eicosanoid and cytokine levels in a rabbit chronic arthritis model. Inhibits proliferation of AML cell lines in vitro.
Technical Data
| M. Wt | 410.66 |
| Formula | C13H10Cl3N3O4S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 276702-15-9 |
| PubChem ID | 9887803 |
| InChI Key | WTLRWOHEKQGKDS-UHFFFAOYSA-N |
| Smiles | ClC1=C(S(=O)(N)=O)C(O)=C(NC(NC2=C(Cl)C(Cl)=CC=C2)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.07 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 410.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.44 mL | 12.18 mL | 24.35 mL |
| 5 mM | 0.49 mL | 2.44 mL | 4.87 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.44 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Podolin et al (2002) A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit. J.Immunol. 169 6435 PMID: 12444152
Schinke et al (2015) IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells. Blood 125 3144 PMID: 25810490
Keywords: SB 332235, supplier, SB332235, chemokines, receptors, CXCR2, interleukin-8, IL-8, inflammation, chronic, acute, rheumatoid, arthritis, antagonists, antagonism, Chemokine, CXC, Receptors, Chemokine, CXC, Receptors, Tocris Bioscience
