Tocris/SB 590885/2650/10/10 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/SB 590885/2650/10/10 mg

Tocris/SB 590885/2650/10/10 mg

商品编号： 2650/10

品牌： Tocris Bioscience

市场价： ¥4700.00

美元价： 2820.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:PotentB-Rafinhibitor

ChemicalName:5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-oneoxime

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentB-Rafinhibitor(K_d=0.3nM).SelectiveforB-Rafagainst46otherkinases(K_iappvaluesare0.16and1.72nMforB-Rafandc-Rafrespectively).Decreasesanchorage-independentgrowthofmelanomacelllines.InhibitsERKphosphorylationandproliferationintumorcellsexpressingB-Raf^V600E.

LicensingInformation

SoldforresearchpurposesunderagreementfromGlaxoSmithKline.

TechnicalData

M.Wt	453.54
Formula	C₂₇H₂₇N₅O₂
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	405554-55-4
PubChemID	11316960
InChIKey	DPCXEUSDRQOOGZ-QLYXXIJNSA-N
Smiles	CN(C)CCOC(C=C4)=CC=C4C1=NC(C3=CC=C(C(CC5)=NO)C5=C3)=C(C2=CC=NC=C2)N1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	4.54	10
	ethanol	2.27	5mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight453.54.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.2mL	11.02mL	22.05mL
5mM	0.44mL	2.2mL	4.41mL
10mM	0.22mL	1.1mL	2.2mL
50mM	0.04mL	0.22mL	0.44mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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SolubilityData

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