Biological Activity
Selective 5-ht5a receptor antagonist (pKi values are 8.3, < 6.0, < 6.0, < 6.0, < 5.5 and < 5.5 for 5-ht5a, 5-HT1B/D, 5-HT2A, 5-HT2C, 5-HT1A and 5-HT7 receptors respectively).
Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline
Technical Data
| M. Wt | 584.66 |
| Formula | C34H45N3O.2HCl |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 864741-95-7 |
| PubChem ID | 11983346 |
| InChI Key | QJMKBIHLMPTYTI-UHFFFAOYSA-N |
| Smiles | O=C(CCC4CCCC4)N(CCN(C)C)CC(C=C2)=CC=C2C1=CC=C(CNCCC3=CC=CC=C3)C=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.62 | 25 | |
| ethanol | 5.85 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 584.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.71 mL | 8.55 mL | 17.1 mL |
| 5 mM | 0.34 mL | 1.71 mL | 3.42 mL |
| 10 mM | 0.17 mL | 0.86 mL | 1.71 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.34 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Thomas et al (2006) SB-69951-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances 5-HT neuronal function: evidence for an auto Neuropharmacology 51 566 PMID: 16846620
Thomas (2006) 5-ht5A receptors as a therapeutic target. Pharmacol.Ther. 111 707 PMID: 16516972
Corbett et al (2005) Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry. Bioorg.Med.Chem.letts. 15 4014 PMID:
Keywords: SB 699551, supplier, Selective, 5-ht5A, antagonists, Serotonin, Receptors, 5-Hydroxytryptamine, SB699551, GlaxoSmithKline, GSK, 5-ht5, Receptors, 5-ht5, Receptors, Tocris Bioscience
