Biological Activity
p38 MAPK inhibitor. Inhibits LPS-induced transcription of a range of chemokines and cytokines in chronic obstructive pulmonary disease (COPD) monocyte derived macrophages (MDMs). Also inhibits LPS-induced protein expression of IL-6, IL-10, TNFα and γ-inducible protein 10 in COPD MDMs. Effects on suppression of LPS-induced gene and protein expression are enhanced in combination with dexamethasone (Cat. No. 1126).
Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline
Technical Data
M. Wt | 492.46 |
Formula | C24H19F3N8O |
Storage | Desiccate at RT |
Purity | ≥98% (HPLC) |
CAS Number | 911110-38-8 |
PubChem ID | 11853799 |
InChI Key | ZQFBVJBAWLZLOM-UHFFFAOYSA-N |
Smiles | N=C(NC#N)NCCNC1=NC(C4=C(C)C=C(F)C=C4)=C(C=CC(N2C3=C(F)C=CC=C3F)=O)C2=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 49.25 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 492.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.03 mL | 10.15 mL | 20.31 mL |
5 mM | 0.41 mL | 2.03 mL | 4.06 mL |
10 mM | 0.2 mL | 1.02 mL | 2.03 mL |
50 mM | 0.04 mL | 0.2 mL | 0.41 mL |
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References
References are publications that support the products' biological activity.
Kent et al (2009) Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl) J.Pharmacol.Exp.Ther. 328 458 PMID: 19004925
Keywords: SB 706504, supplier, SB706504, p38, MAPK, inhibitors, map, kinases, inhibits, dexamethasone, inflammatory, cytokines, p38, p38, Tocris Bioscience