BiologicalActivity
p38MAPKinhibitor.InhibitsLPS-inducedtranscriptionofarangeofchemokinesandcytokinesinchronicobstructivepulmonarydisease(COPD)monocytederivedmacrophages(MDMs).AlsoinhibitsLPS-inducedproteinexpressionofIL-6,IL-10,TNFαandγ-inducIBLeprotein10inCOPDMDMs.EffectsonsuppressionofLPS-inducedgeneandproteinexpressionareenhancedincombinationwithdexamethasone(Cat.No.1126).
LicensingInformation
SoldforresearchpurposesunderagreementfromGlaxoSmithKline
TechnicalData
| M.Wt | 492.46 |
| Formula | C24H19F3N8O |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 911110-38-8 |
| PubChemID | 11853799 |
| InChIKey | ZQFBVJBAWLZLOM-UHFFFAOYSA-N |
| Smiles | N=C(NC#N)NCCNC1=NC(C4=C(C)C=C(F)C=C4)=C(C=CC(N2C3=C(F)C=CC=C3F)=O)C2=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.25 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight492.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.03mL | 10.15mL | 20.31mL |
| 5mM | 0.41mL | 2.03mL | 4.06mL |
| 10mM | 0.2mL | 1.02mL | 2.03mL |
| 50mM | 0.04mL | 0.2mL | 0.41mL |
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