BiologicalActivity
SelectiveinhibitorofPLK1(IC50valuesare200pM,875nMand66μMforPLK1,PLK3andPLK2respectively).ExhibitsnoeffectonAurorakinaseAactivity.BindsandstABIlizestheinactiveformofPLK1.Delayscellcycleprogression,reducescellproliferationandinducesapoptosisinarangeofhumancancercelllines.TransientlyarrestscellscycleatG0/G1inprimarycells.
CompoundLibraries
SBE13hydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 479.4 |
| Formula | C24H27ClN2O4.HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 1052532-15-6 |
| PubChemID | 11948807 |
| InChIKey | QBGSVDJLQQXEGG-UHFFFAOYSA-N |
| Smiles | ClC(N=C3)=CC=C3COC1=C(OC)C=C(CNCCC2=CC(OC)=C(OC)C=C2)C=C1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.94 | 100 | |
| ethanol | 4.79 | 10mMwithgentlewarming | |
| water | 4.79 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight479.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.09mL | 10.43mL | 20.86mL |
| 5mM | 0.42mL | 2.09mL | 4.17mL |
| 10mM | 0.21mL | 1.04mL | 2.09mL |
| 50mM | 0.04mL | 0.21mL | 0.42mL |
MolarityCalculator
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ProductDatasheets
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