Biological Activity
Selective COX-2 inhibitor (IC50 values are 0.005 and 17.8 μM for COX-2 and COX-1 respectively). Displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries
SC 236 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 401.79 |
| Formula | C16H11ClF3N3O2S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 170569-86-5 |
| PubChem ID | 9865808 |
| InChI Key | NSQNZEUFHPTJME-UHFFFAOYSA-N |
| Smiles | ClC(C=C3)=CC=C3C1=CC(C(F)(F)F)=NN1C2=CC=C(S(=O)(N)=O)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.18 | 100 | |
| ethanol | 40.18 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 401.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.49 mL | 12.44 mL | 24.89 mL |
| 5 mM | 0.5 mL | 2.49 mL | 4.98 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.49 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Gierse et al (1996) A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors. J.Biol.Chem. 271 15810 PMID: 8663121
Roche-Nagle et al (2004) Antimetastatic activity of a cyclooxygenase-2 inhibitor. Br.J.Cancer 91 359 PMID: 15213717
Penning et al (1997) Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib). J.Med.Chem. 40 1347 PMID: 9135032
Keywords: SC 236, supplier, SC236, SC58236, selective, cyclooxygenase-2, COX-2, inhibitors, inhibits, Pfizer, SC, 58236, Cyclooxygenase, Cyclooxygenase, Tocris Bioscience
