Biological Activity
Allosteric inhibitor of Akt; interferes with pleckstrin homology domain binding to PIP3 and facilitates Akt ubiquitination. Exhibits anticancer activity in vitro and in vivo.
Technical Data
| M. Wt | 276.33 |
| Formula | C18H16N2O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 871361-88-5 |
| PubChem ID | 6018993 |
| InChI Key | CYVVJSKZRBZHAV-UNZYHPAISA-N |
| Smiles | O=C(/C(CCC3)=C/C2=CC=NC=C2)/C3=C/C1=CC=NC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.72 | 75 | |
| ethanol | 20.72 | 75 |
Preparing Stock Solutions
The following data is based on the product molecular weight 276.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.62 mL | 18.09 mL | 36.19 mL |
| 5 mM | 0.72 mL | 3.62 mL | 7.24 mL |
| 10 mM | 0.36 mL | 1.81 mL | 3.62 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Jo et al (2011) Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Proc.Natl.Acad.Sci.USA 108 6486 PMID: 21464312
Keywords: SC 66, supplier, SC66, akt, pkb, protein, kinase, b, inhibitors, inhibits, allosteric, dual, activity, inhibitory, Akt, (Protein, Kinase, B), Protein, Kinase, B/Akt, Akt, (Protein, Kinase, B), Tocris Bioscience
