Biological Activity
A selective, competitive and orally active GABAB antagonist. Displays an IC50 of 1.1 μM at GABAB, approximately 60 times that of CGP 35348 (Cat. No. 1245) and no binding affinity for GABAA at concentrations up to 100 μM.
Licensing Information
Sold with the permission of Schering Plough Corporation
Technical Data
| M. Wt | 173.21 |
| Formula | C8H15NO3 |
| Storage | Desiccate at -20°C |
| Purity | ≥98% |
| CAS Number | 733717-87-8 |
| PubChem ID | 5311429 |
| InChI Key | SEYCKMQSPUVYEF-LURJTMIESA-N |
| Smiles | [H][C@]1(CC(O)=O)CNC(C)(C)CO1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| phosphate buffered saline | 17.32 | 100 | |
| water | 17.32 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 173.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.77 mL | 28.87 mL | 57.73 mL |
| 5 mM | 1.15 mL | 5.77 mL | 11.55 mL |
| 10 mM | 0.58 mL | 2.89 mL | 5.77 mL |
| 50 mM | 0.12 mL | 0.58 mL | 1.15 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Bolser et al (1995) The pharmacology of SCH 50911: a novel, orally active GABA-B receptor antagonist. J.Pharmacol.Exp.Ther. 274 1393 PMID: 7562513
Hosford et al (1995) Characterization of the antiabsence effects of SCH 50911, a GABAB receptor antagonist, in the lethargic mouse, γ-hydroxybutyrate, and pentylenetetrazole models. J.Pharmacol. Exp.Ther. 274 1399 PMID: 7562514
Ong et al (1998) The morpholino-acetic acid analogue Sch 50911 is a selective GABAB receptor antagonist in rat neocortical slices. Eur.J.Pharmacol. 362 35 PMID: 9865527
Blythin et al (1996) Substituted morpholine-2S-acetic acid derivatives: SCH 50911 and related compounds as novel GABAB antagonists. Bioorg.Med.Chem.Lett. 6 1529 PMID:
Keywords: SCH 50911, supplier, Selective, competitive, orally, active, GABAB, antagonist, Receptors, SCH50911, GABAB, Receptors, GABAB, Receptors, Tocris Bioscience
