Biological Activity
Potent and highly selective non-peptide δ receptor antagonist (Ki values are 4.7, 3800 and 7900 nM for δ, κ and μ receptors respectively). More selective than naltrindole (Cat. No. 0740). Also inhibits Dengue virus replication.
Compound Libraries
SDM25N hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 450.96 |
| Formula | C26H26N2O3.HCl |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 342884-71-3 |
| PubChem ID | 90479789 |
| InChI Key | QLLCUVACGPLGAX-XXCZMEBESA-N |
| Smiles | O[C@@]24[C@]3([C@@H]7C(N6)=C(C5=C6C=CC=C5)C4)C1=C(O7)C(O)=CC=C1CC2N(CC(C)=C)CC3.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.09 | 100 | |
| ethanol | 45.09 | 100 | |
| water | 4.5 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 450.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.22 mL | 11.09 mL | 22.17 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.43 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.22 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
McLamore et al (2001) Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7:2 ',3 '-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy. J.Med.Chem. 44 1471 PMID: 11311071
Sprokholt et al (2017) RIG-I-like receptor triggering by Dengue virus drives dendritic cell immune activation and TH1 differentiation. J.Immunol. PMID: 28507028
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