Biological Activity
5-HT3/5-HT4 receptor antagonist.
Technical Data
| M. Wt | 337.25 |
| Formula | C14H21ClN2O3.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1197334-02-3 |
| PubChem ID | 11957705 |
| InChI Key | JOWUQCJWCRNVMQ-UHFFFAOYSA-N |
| Smiles | Cl.CCN(CC)CCOC(=O)C1=CC(Cl)=C(N)C=C1OC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 33.73 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 337.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.97 mL | 14.83 mL | 29.65 mL |
| 5 mM | 0.59 mL | 2.97 mL | 5.93 mL |
| 10 mM | 0.3 mL | 1.48 mL | 2.97 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Eglen et al (1993) The action of SDZ 205,557 at 5-hydroxytryptamine (5-HT3 and 5-HT4) receptors. Br.J.Pharmacol. 108 376 PMID: 8448587
McMahon and Cunningham (1999) Antagonism of 5-hydroxytryptamine(4) receptors attenuates hyperactivity induced by cocaine: putative role for 5-hydroxytryptamine(4) receptors in the nucleus accumbens shell. J.Pharmacol.Exp.Ther. 291 300 PMID: 10490917
Buchheit et al (1992) SDZ 205-557, a selective, surmountable antagonist for 5-HT4 receptors in the isolated guinea pig ileum. Naunyn-Schmied.Arch.Pharmacol. 345 387 PMID:
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