Biological Activity
Competitive NMDA receptor antagonist (pKi = 7.7). Centrally active following oral administration (ED50 < 3.2 mg/kg for protection against MES-induced seizures).
Licensing Information
Sold with the permission of Novartis Pharma AG
Compound Libraries
SDZ 220-581 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 369.74 |
| Formula | C16H17ClNO5P |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 174575-17-8 |
| PubChem ID | 128019 |
| InChI Key | VBRJFXSFCYEZMQ-HNNXBMFYSA-N |
| Smiles | OC([C@@H](N)CC1=CC(C2=CC=CC=C2Cl)=CC(CP(O)(O)=O)=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1.1eq. NaOH | 36.97 | 100 | |
| 1eq. HCl | 3.69 | 10mM with gentle warming | |
| DMSO | 9.24 | 25mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 369.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.7 mL | 13.52 mL | 27.05 mL |
| 5 mM | 0.54 mL | 2.7 mL | 5.41 mL |
| 10 mM | 0.27 mL | 1.35 mL | 2.7 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Bakshi et al (1999) Disruption of prepulse inhibition and increases in locomotor activity by competitive N-methyl-D-aspartate receptor antagonists in rats. J.Pharmacol.Exp.Ther. 288 643 PMID: 9918570
Urwyler et al (1996) Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists - I. Pharmacological characterization in vitro. Neuropharmacology 35 643 PMID: 8887974
Urwyler et al (1996) Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists - II. Pharmacological characterization in vivo. Neuropharmacology 35 655 PMID: 8887975
Keywords: SDZ 220-581, supplier, Competitive, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, SDZ220-581, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience
