Biological Activity
Amyloid-β (Aβ) aggregation inhibitor; blocks Aβ(1-42) aggregation and protects neuronal cell lines exposed to Aβ(1-42). Reduces Aβ oligomer-induced LTP and memory deficits in vivo.
Compound Libraries
SEN 1269 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 322.36 |
| Formula | C18H18N4O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 956128-01-1 |
| PubChem ID | 46835756 |
| InChI Key | MFPAAKZZUIRMKR-UHFFFAOYSA-N |
| Smiles | OC1=CC(NC2=NC=C(OC3=CC=CC(N(C)C)=C3)C=N2)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.24 | 100 | |
| ethanol | 16.12 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 322.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.1 mL | 15.51 mL | 31.02 mL |
| 5 mM | 0.62 mL | 3.1 mL | 6.2 mL |
| 10 mM | 0.31 mL | 1.55 mL | 3.1 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Scopes et al (2012) Aβ oligomer toxicity inhibitor protects memory in models of synaptic toxicity. Br.J.Pharmacol. 167 383 PMID: 22913627
Keywords: SEN 1269, supplier, SEN1269, Amyloid-β, (Aβ), aggregation, inhibitors, inhibits, LTP, memory, Alzheimer's, amyloidbeta, amyloidb, Amyloid, Beta, Peptides, Amyloid, Beta, Peptides, Tocris Bioscience
