BiologicalActivity
Potentallostericinhibitorofproteinargininemethyltransferase3(PRMT3)(IC50=31nM).InhibitsPRMT3-mediatedmethyltransferaseactivityinvitro.Displays>100-foldselectivityagainst31othermethyltransferasesand250othernon-epigenetictargets.
LicensingInformation
ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheSGC707probesummaryontheSGCwebsite.
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofSGC707isreviewedonthechemicalprobeswebsite.
CompoundLibraries
SGC707isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 298.34 |
| Formula | C16H18N4O2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| PubChemID | 90642938 |
| InChIKey | DMIDPTCQPIJYFE-UHFFFAOYSA-N |
| Smiles | O=C(NCC(N1CCCC1)=O)NC2=CC3=CC=NC=C3C=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 29.83 | 100 | |
| DMSO | 29.83 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight298.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.35mL | 16.76mL | 33.52mL |
| 5mM | 0.67mL | 3.35mL | 6.7mL |
| 10mM | 0.34mL | 1.68mL | 3.35mL |
| 50mM | 0.07mL | 0.34mL | 0.67mL |
MolarityCalculator
ReconstitutionCalculator
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ProductDatasheets
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