Biological Activity
Potent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50 = 31 nM). Inhibits PRMT3-mediated methyltransferase activity in vitro. Displays >100-fold selectivity against 31 other methyltransferases and 250 other non-epigenetic targets.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC 707 probe summary on the SGC website.
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGC 707 is reviewed on the chemical probes website.
Compound Libraries
SGC 707 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 298.34 |
| Formula | C16H18N4O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 90642938 |
| InChI Key | DMIDPTCQPIJYFE-UHFFFAOYSA-N |
| Smiles | O=C(NCC(N1CCCC1)=O)NC2=CC3=CC=NC=C3C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 29.83 | 100 | |
| DMSO | 29.83 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 298.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.35 mL | 16.76 mL | 33.52 mL |
| 5 mM | 0.67 mL | 3.35 mL | 6.7 mL |
| 10 mM | 0.34 mL | 1.68 mL | 3.35 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.67 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Kaniskan et al (2015) A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angew.Chem.Int.Ed.Engl 54 5166 PMID: 25728001
Keywords: SGC 707, supplier, SGC707, Potent, allosteric, inhibitors, inhibits, of, protein, arginine, methyltransferase, 3, PRMT3, Protein, Arginine, Methyltransferases, Protein, Arginine, Methyltransferases, Tocris Bioscience
