Biological Activity
Selective antagonist of the 5-HT6 subtype of the serotonin receptor. Useful for the treatment of cognitive impairment that is associated with schizophrenia and Alzheimer's disease.
Technical Data
| M. Wt | 510.51 |
| Formula | C21H22F2N2O3S.C2H2O4 |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 445441-27-0 |
| PubChem ID | 24880040 |
| InChI Key | XQGFYENETWVJEU-UHFFFAOYSA-N |
| Smiles | CN2C1=CC=C(OS(C4=C(F)C=CC=C4F)(=O)=O)C=C1C(C3CCN(C)CC3)=C2.OC(C(O)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.05 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 510.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.96 mL | 9.79 mL | 19.59 mL |
| 5 mM | 0.39 mL | 1.96 mL | 3.92 mL |
| 10 mM | 0.2 mL | 0.98 mL | 1.96 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.39 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Kim et al (2008) New serotonin 5-HT6 ligands from common feature pharmacophore hypotheses. J.Chem.Inf.Model. 48 197 PMID: 18044950
Romero et al (2006) Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways. Br.J.Pharmocol. 148 1133 PMID: 16865095
Keywords: SGS 518 oxalate, supplier, SGS518, 5-HTreceptors, serotonin, antagonists, schizophrenia, Alzheimers, LY483518, LY, 483518, 5-HT6, Receptors, 5-HT6, Receptors, Tocris Bioscience
