Biological Activity
Potent and selective c-MET kinase inhibitor (IC50 = 4nM). Exhibits minimal inhibition against a panel of 213 other protein kinases (at 1 μM). Suppresses growth of tumor xenografts derived from human glioblastoma, lung and gastric cancer cells.
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGX 523 is reviewed on the chemical probes website.
Technical Data
| M. Wt | 359.41 |
| Formula | C18H13N7S |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1022150-57-7 |
| PubChem ID | 24779724 |
| InChI Key | BCZUAADEACICHN-UHFFFAOYSA-N |
| Smiles | CN1N=CC(C(C=C2)=NN3C2=NN=C3SC4=CC5=CC=CN=C5C=C4)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.19 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 359.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.78 mL | 13.91 mL | 27.82 mL |
| 5 mM | 0.56 mL | 2.78 mL | 5.56 mL |
| 10 mM | 0.28 mL | 1.39 mL | 2.78 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Buchanan et al (2009) SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. Mol.Cancer.Ther. 8 3181 PMID: 19934279
Keywords: SGX 523, supplier, SGX523, Selective, potent, c-MET, kinase, inhibitors, inhibits, MET, Receptors, MET, Receptors, Tocris Bioscience
