Biological Activity
Potent and reversible human cathepsin L inhibitor (IC50 = 56 nM). Displays no inhibitory activity at cathepsin G. Antimalarial; inhibits leishmaniasis.
Technical Data
| M. Wt | 539.65 |
| Formula | C27H33N5O5S |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 958772-66-2 |
| PubChem ID | 16725315 |
| InChI Key | OTIWAYTTYNFEKL-QFIPXVFZSA-N |
| Smiles | O=C(NNC(SCC(NC1=C(CC)C=CC=C1)=O)=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(OC(C)(C)C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.98 | 50 | |
| ethanol | 5.4 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 539.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.85 mL | 9.27 mL | 18.53 mL |
| 5 mM | 0.37 mL | 1.85 mL | 3.71 mL |
| 10 mM | 0.19 mL | 0.93 mL | 1.85 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.37 mL |
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References
References are publications that support the products' biological activity.
Shah et al (2008) Kinetic characterization and molecular docking of a novel, potent and selective slow-binding inhibitor of human cathepsin L. Mol.Pharmacol. 74 34 PMID: 18403718
Myers et al (2008) Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor. Bioorg.Med.Chem.Lett. 18 210 PMID: 18060772
Keywords: SID 26681509, supplier, SID26681509, cathepsin, L, inhibitors, inhibits, cysteine, protease, antimalarial, Cathepsin, Calcium-Sensitive, Proteases, Cathepsin, Tocris Bioscience
