Biological Activity
Selective dopamine D1-like receptor partial agonist (IC50 values are 19.7 and 2425 nM for binding to D1-like and D2-like receptors respectively). Centrally active following systemic administration in vivo.
Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline
Technical Data
| M. Wt | 376.29 |
| Formula | C19H21NO2.HBr |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 300561-58-4 |
| PubChem ID | 11957703 |
| InChI Key | JWQRAXTWDYUBFI-UHFFFAOYSA-N |
| Smiles | Br.OC1=CC2=C(C=C1O)C(CN(CC=C)CC2)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.54 | 100 | |
| ethanol | 2.95 | 10 | |
| water | 3.76 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 376.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.66 mL | 13.29 mL | 26.58 mL |
| 5 mM | 0.53 mL | 2.66 mL | 5.32 mL |
| 10 mM | 0.27 mL | 1.33 mL | 2.66 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Briggs et al (1991) Activation of the 5-HT1C receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393. Br.J.Pharmacol. 104 1038 PMID: 1687364
Meyer and Schults (1993) Dopamine D1 receptor family agonists, SK&F38393, SK&F77434, and SK&F82958, differentially affect locomotor activities in rats. Pharmacol.Biochem.Behav. 46 269 PMID: 7903456
Neumeyer et al (1992) Stereoisomeric probes for the D1 dopamine receptor: synthesis and characterization of R-(+) and S-(-) enantiomers of 3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its 6-bromo analogue. J.Med.Chem. 35 1466 PMID: 1533424
Keywords: SKF 77434 hydrobromide, supplier, Selective, D1-like, partial, agonists, Dopamine, Receptors, D5, dopaminergic, SKF77434, hydrobromide, GlaxoSmithKline, GSK, D1, and, D5, Receptors, D1, and, D5, Receptors, Tocris Bioscience
