Biological Activity
Dopamine D1-like receptor agonist. Centrally active following systemic administration in vivo.
Compound Libraries
SKF 81297 hydrobromide is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 370.67 |
| Formula | C16H16ClNO2.HBr |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 67287-39-2 |
| PubChem ID | 11957706 |
| InChI Key | RMIJGBMRNYUZRG-UHFFFAOYSA-N |
| Smiles | Br.OC1=C(O)C(Cl)=C2CCNCC(C3=CC=CC=C3)C2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.07 | 100 | |
| water | 3.71 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 370.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.7 mL | 13.49 mL | 26.98 mL |
| 5 mM | 0.54 mL | 2.7 mL | 5.4 mL |
| 10 mM | 0.27 mL | 1.35 mL | 2.7 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Arnt et al (1988) Relative dopamine D1 and D2 receptor affinity and efficacy determine whether dopamine agonists induce hyperactivity or oral stereotypy in rats. Pharmacol.Toxicol. 62 121 PMID: 3259694
Peacock et al (1990) The effects of dopamine D1 and D2 receptor agonists and antagonists in monkeys withdrawn from long-term neuroleptic treatment. Eur.J.Pharmacol. 186 49 PMID: 1980891
Reavill et al (1993) Pharmacological characterization of the discriminative stimulus properties of the dopamine D1 agonist, SKF 81297. Behav.Pharmacol. 4 135 PMID: 11224180
Keywords: SKF 81297 hydrobromide, supplier, D1, agonists, Dopamine, Receptors, D5, dopaminergic, SKF81297, hydrobromide, D1, and, D5, Receptors, D1, and, D5, Receptors, Tocris Bioscience
