Biological Activity
D1 agonist. Increases renal blood flow in animal models and promotes contralateral rotation in rats with unilateral lesions of the substantia nigra. Also augments GABAB inhibitory post-synaptic potentials (ipsp) in ventral tegmental area in brain slices.
Technical Data
| M. Wt | 410.73 |
| Formula | C19H20ClNO2.HBr |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 74115-01-8 |
| PubChem ID | 9909521 |
| InChI Key | WLXGFAVTAAQOFH-UHFFFAOYSA-N |
| Smiles | OC1=CC(C(C2=CC=CC=C2)CN(CC=C)CC3)=C3C(Cl)=C1O.Br |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.07 | 100 | |
| water | 2.05 | 5mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 410.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.43 mL | 12.17 mL | 24.35 mL |
| 5 mM | 0.49 mL | 2.43 mL | 4.87 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.43 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
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References
References are publications that support the products' biological activity.
Pfeiffer et al (1982) Dopaminergic activity of substituted 6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines. J.Med.Chem. 25 352 PMID: 7069713
Cameron and Williams (1993) Dopamine D1 receptors facilitate transmitter release. Nature 366 344 PMID: 8247128
Keywords: SKF 82958 hydrobromide, supplier, SKF82958, hydrobromide, dopamine, D1, agonists, agonism, D1, and, D5, Receptors, D1, and, D5, Receptors, Tocris Bioscience
