Biological Activity
High affinity, selective dopamine D1-like receptor agonist. Ki values are 3.2, 3.1, 186, 66, 335, 1167, 1251 and 1385 nM at recombinant D1, D5, D2, D3, D4, 5-HT2A, α1A and α1B receptors respectively. Stimulates adenylyl cyclase (EC50 = 65 nM) but not phosphoinositide hydrolysis. Induces extreme arousal and hyperlocomotion following subcutaneous administration in monkeys.
Technical Data
| M. Wt | 424.76 |
| Formula | C20H22ClNO2.HBr |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 74115-10-9 |
| PubChem ID | 12909789 |
| InChI Key | CFWPKYBBXBANLU-UHFFFAOYSA-N |
| Smiles | ClC1=C(O)C(O)=CC2=C1CCN(CC=C)CC2C3=CC=CC(C)=C3.Br |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.38 | 100 | |
| ethanol | 3.44 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 424.76. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.35 mL | 11.77 mL | 23.54 mL |
| 5 mM | 0.47 mL | 2.35 mL | 4.71 mL |
| 10 mM | 0.24 mL | 1.18 mL | 2.35 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
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References
References are publications that support the products' biological activity.
Undie et al (1994) Evidence for a distinct D1-like dopamine receptor that couples to activation of phosphoinositide metabolism in brain. J.Neurochem. 62 2045 PMID: 7908949
Peacock and Gerlach (2001) Aberrant behavioural effects of a dopamine D1 receptor antagonist and agonist in monkeys: evidence of uncharted dopamine D1 receptor actions. Biol.Psychiatry 50 501 PMID: 11600103
O'Sullivan et al (2004) SK&F 83822 distinguishes adenylyl cyclase from phospholipase C-coupled D1-like receptors: behavioural topography. Eur.J.Pharmacol. 486 273 PMID: 14985049
Keywords: SKF 83822 hydrobromide, supplier, Selective, D1-like, agonists, Dopamine, D1, Receptors, D5, dopaminergic, SKF83822, hydrobromide, D1, and, D5, Receptors, D1, and, D5, Receptors, Tocris Bioscience
