Biological Activity
Store-operated Ca2+ entry (SOCE) inhibitor that inhibits STIM1. Also blocks TRPC channels, voltage-gated Ca2+ channels and potassium channels.
Technical Data
| M. Wt | 402.92 |
| Formula | C22H26N2O3.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 130495-35-1 |
| PubChem ID | 104955 |
| InChI Key | FWLPKVQUECFKSW-UHFFFAOYSA-N |
| Smiles | Cl.COC1=CC=C(CCCOC(CN2C=CN=C2)C2=CC=C(OC)C=C2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 402.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.48 mL | 12.41 mL | 24.82 mL |
| 5 mM | 0.5 mL | 2.48 mL | 4.96 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.48 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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References
References are publications that support the products' biological activity.
Merritt et al (1990) SK&F96365, a novel inhibitor of receptor-mediated calcium entry. Biochem.J. 271 515 PMID: 2173565
Varnai et al (2009) STIM and Orai: the long-awaited constituents of store-operated calcium entry. TiPS 30 118 PMID: 19187978
Singh et al (2010) The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels. Br.J.Pharmacol. 160 1464 PMID: 20590636
Keywords: SKF 96365 hydrochloride, supplier, STIM1-mediated, Ca2+, influx, inhibitos, receptor-mediated, entry, Store, Operated, Calcium, Channels, STIM-Orai, Signaling, Signalling, Agents, General, SKF96365, hydrochloride, General, Calcium, Signaling, Agents, STIM-Orai, Channels, TRPC, TRPC, Tocris Bioscience
