Biological Activity
Very potent GABAB agonist, at least ten times more active than baclofen (Cat. No. 0417). Also GABAA-ρ antagonist.
Technical Data
| M. Wt | 137.12 |
| Formula | C4H12NO2P |
| Storage | Desiccate at RT |
| CAS Number | 127729-35-5 |
| PubChem ID | 5230 |
| InChI Key | NHVRIDDXGZPJTJ-UHFFFAOYSA-N |
| Smiles | NCCCP(O)(C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 13.71 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 137.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 7.29 mL | 36.46 mL | 72.93 mL |
| 5 mM | 1.46 mL | 7.29 mL | 14.59 mL |
| 10 mM | 0.73 mL | 3.65 mL | 7.29 mL |
| 50 mM | 0.15 mL | 0.73 mL | 1.46 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Bon and Galvan (1996) Electrophysiological characterization of GABAB agonists and antagonists in dorso-lateral septal neurones in vitro. Br.J.Pharmacol. 118 961 PMID: 8799569
Froestl et al (1995) Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. J.Med.Chem. 38 3297 PMID: 7650684
Johnston (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319 PMID: 8885697
Seabrook et al (1990) Electrophysiological characterization of potent agonists and antagonists on pre- and postsynaptic GABAB receptors on neurones in brain slices. Br.J.Pharmacol. 101 949 PMID: 1964824
Keywords: SKF 97541, supplier, potent, GABAB, agonists, GABAC, antagonists, Receptors, SKF97541, CGP35024, CGP, 35024, GABAB, Receptors, GABAA-rho, Receptors, GABAB, Receptors, Tocris Bioscience
