Biological Activity
Protease-activated receptor 2 (PAR2) agonist (Ki = 9.64 μM and IC50 = 10.4 μM). Corresponds to the tethered ligand exposed by trypsin cleavage of PAR-2. Control peptide VKGILS-NH2 also available (Cat. No. 3392).
Technical Data
| M. Wt | 614.78 |
| Formula | C28H54N8O7 |
| Sequence |
SLIGKV (Modifications: Val-6 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 190383-13-2 |
| PubChem ID | 10483914 |
| InChI Key | HOWDUIVVWDUEED-WAUHAFJUSA-N |
| Smiles | [H]N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 614.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.63 mL | 8.13 mL | 16.27 mL |
| 5 mM | 0.33 mL | 1.63 mL | 3.25 mL |
| 10 mM | 0.16 mL | 0.81 mL | 1.63 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.33 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Bohm et al (1996) Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem.J. 314 1009 PMID: 8615752
Hollenberg and Compton (2002) International union of pharmacology XXVIII. Proteinase-activated receptors. Pharmacol.Rev. 54 203 PMID: 12037136
Kanke et al (2005) Binding of a highly potent protease-activated receptor-2 (PAR2) activating peptide, [3H]2-furoyl-LIGRL-NH2, to human PAR2. Br.J.Pharmacol. 145 255 PMID: 15765104
Keywords: SLIGKV-NH2, supplier, PAR2, receptor, agonists, Receptors, Protease-Activated, proteinase-activated, Protease-Activated, Receptors, Protease-Activated, Receptors, Tocris Bioscience
