Biological Activity
Potent TLR7 agonist (EC50 = 50 nM). Exhibits selectivity for TLR7 over TLR8. Induces IFN-α and -γ expression in human PBMCs and mouse splenocytes, and inhibits IL-5 production in human PBMCs in vitro. Rapidly metabolized to acid metabolite (t½ = 2.6 min in human plasma).
Technical Data
| M. Wt | 385.42 |
| Formula | C19H23N5O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 677773-91-0 |
| PubChem ID | 23079483 |
| InChI Key | MXILFZWMVNDOIZ-UHFFFAOYSA-N |
| Smiles | NC1=NC(OCCCC)=NC(N2CC3=CC=CC(CC(OC)=O)=C3)=C1NC2=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.54 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 385.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.59 mL | 12.97 mL | 25.95 mL |
| 5 mM | 0.52 mL | 2.59 mL | 5.19 mL |
| 10 mM | 0.26 mL | 1.3 mL | 2.59 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Kurimoto et al (2010) Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept. J.Med.Chem. 53 2964 PMID: 20232824
Biffen et al (2012) Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity. Br.J.Pharmacol. 166 573 PMID: 22122192
Keywords: SM 324405, supplier, SM324405, toll-like, receptors, TLR7, potent, agonists, agonism, Toll-like, Receptors, Toll-like, Receptors, Tocris Bioscience
