Biological Activity
GABA transport inhibitor, showing selectivity for GAT-3 and GAT-2 (IC50 values are 5, 21 and 388 μM for hGAT-3, rGAT-2 and hGAT-1 respectively). Increases thalamic GABA levels and is an anticonvulsant following systemic administration in vivo.
Technical Data
| M. Wt | 505.61 |
| Formula | C30H35NO6 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 157604-55-2 |
| PubChem ID | 10458835 |
| InChI Key | VDLDUZLDZBVOAS-QFIPXVFZSA-N |
| Smiles | O=[C@]([C@@H]1CN(CCOC(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C2=CC=C(OC)C=C2)CCC1)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.56 | 100 | |
| ethanol | 25.28 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 505.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.98 mL | 9.89 mL | 19.78 mL |
| 5 mM | 0.4 mL | 1.98 mL | 3.96 mL |
| 10 mM | 0.2 mL | 0.99 mL | 1.98 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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References
References are publications that support the products' biological activity.
Borden et al (1994) Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site. Receptors Channels 2 207 PMID: 7874447
Borden (1996) GABA transporter heterogeneity: pharmacology and cellular localization. Neurochem.Int. 29 335 PMID: 8939442
Dalby (2000) GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors. Neuropharmacology 39 2399 PMID: 10974324
Keywords: (S)-SNAP 5114, supplier, GABA, reuptake, inhibitors, inhibits, BGT-1, GAT-2, GAT-3, Transporters, Monoamine, Neurotransmitter, (S)-SNAP5114, GABA, Transporters, GABA, Transporters, Tocris Bioscience
