Biological Activity
A highly selective and potent non-peptide δ-opioid agonist, 2000-fold selective over μ-opioid receptors.
Compound Libraries
SNC 80 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 449.64 |
| Formula | C28H39N3O2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 156727-74-1 |
| PubChem ID | 123924 |
| InChI Key | KQWVAUSXZDRQPZ-UMTXDNHDSA-N |
| Smiles | [H][C@@](N1C[C@@H](C)N(CC=C)C[C@@H]1C)(C1=CC=C(C=C1)C(=O)N(CC)CC)C1=CC=CC(OC)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 44.96 | 100mM with gentle warming | |
| DMSO | 8.99 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 449.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.22 mL | 11.12 mL | 22.24 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.45 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.22 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Bilsky et al (1995) SNC 80, a selective, nonpeptidic and systemically active opioid δ agonist. J.Pharmacol.Exp.Ther. 273 359 PMID: 7714789
Calderon et al (1994) Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC80): a highly selective nonpeptid J.Med.Chem. 37 2125 PMID: 8035418
Knapp et al (1996) Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors. J.Pharmacol.Exp.Ther. 277 1284 PMID: 8667189
Keywords: SNC 80, supplier, selective, non-peptide, δ-opioid, delta-opioid, agonists, DOP, Receptors, OP1, SNC80, Delta, Opioid, Receptors, Delta, Opioid, Receptors, Tocris Bioscience
