Biological Activity
Potent inhibitor of cyclin-dependent kinases (cdks) 9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively). Displays no activity against 190 additional kinases (IC50 >1000 nM). Arrests the cell cycle at G2/M; inhibits transcription, proliferation and colony formation, and induces apoptosis in RPMI-8226 multiple myeloma cells. Prevents tumor cell-induced VEGF secretion and in vitro angiogenesis.
Technical Data
| M. Wt | 380.53 |
| Formula | C17H24N4O2S2 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 345627-80-7 |
| PubChem ID | 3025986 |
| InChI Key | OUSFTKFNBAZUKL-UHFFFAOYSA-N |
| Smiles | CC(C)(C)C1=CN=C(CSC2=CN=C(NC(C3CCNCC3)=O)S2)O1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.03 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 380.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.63 mL | 13.14 mL | 26.28 mL |
| 5 mM | 0.53 mL | 2.63 mL | 5.26 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.63 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
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References
References are publications that support the products' biological activity.
Misra et al (2004) N-(Cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent J.Med.Chem. 47 1719 PMID: 15027863
Ali et al (2007) SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor. Neoplasia 9 370 PMID: 17534442
Conroy et al (2009) SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples. Cancer Chemother.Pharmacol. 64 723 PMID: 19169685
Chen et al (2010) Responses in mantle cell lymphoma cells to SNS-032 depend on the biological context of each cell line. Cancer Res. 70 6587 PMID: 20663900
Keywords: SNS 032, supplier, SNS032, inhibits, cyclin-depndent, kinase, Cdk, potent, inhibitors, cdk2, cdk7, cdk9, BMS387032, BMS, 387032, BMS-387032, Cyclin-dependent, Kinase, Cyclin-dependent, Kinase, Tocris Bioscience
