BiologicalActivity
SelectiveJNKinhibitor.CompetitivelyandreversIBLyinhibitsJNK1,2and3(IC50=40-90nM)withnegligibleactivityatERK2,p38βandarangeofenzymes.Activeinvivo.Exhibitsreducedselectivityoverotherproteinkinasesundercertainconditions.Protectsrenaltubularepithelialcellsagainstischemia/reperfusion-inducedapoptosis.PreventsBMP9-inducedosteogenicdifferentiationofMSCs.Essentialcomponentofmediumformaintainingstemcellsinnaivepluripotentstate.AvailableaspartoftheMAPKInhibitorTocriset™.
CompoundLibraries
SP600125isalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 220.23 |
| Formula | C14H8N2O |
| Storage | Desiccateat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 129-56-6 |
| PubChemID | 8515 |
| InChIKey | ACPOUJIDANTYHO-UHFFFAOYSA-N |
| Smiles | O=C1C2=C3C(NN=C3C3=CC=CC=C13)=CC=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.02 | 100 | |
| ethanol | 1.1 | 5mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight220.23.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.54mL | 22.7mL | 45.41mL |
| 5mM | 0.91mL | 4.54mL | 9.08mL |
| 10mM | 0.45mL | 2.27mL | 4.54mL |
| 50mM | 0.09mL | 0.45mL | 0.91mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
本网站将在规定时间内给予删除等相关处理。
