Biological Activity
Inhibitor of adenylyl cyclase (IC50 = 1.4 μM). Inhibits PGE1-stimulated increases in cAMP levels in intact human platelets.
Compound Libraries
SQ 22536 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 205.22 |
| Formula | C9H11N5O |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 17318-31-9 |
| PubChem ID | 5270 |
| InChI Key | UKHMZCMKHPHFOT-UHFFFAOYSA-N |
| Smiles | NC1=C2N=CN(C3CCCO3)C2=NC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.26 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 205.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.87 mL | 24.36 mL | 48.73 mL |
| 5 mM | 0.97 mL | 4.87 mL | 9.75 mL |
| 10 mM | 0.49 mL | 2.44 mL | 4.87 mL |
| 50 mM | 0.1 mL | 0.49 mL | 0.97 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Fabbri et al (1991) Inhibition of adenylate cyclase of catfish and rat hepatocyte membranes by 9-(tetrahydro-2-furyl)adenine (SQ 22536). J.Enzyme Inhib. 5 87 PMID: 1669444
Harris et al (1979) Inhibition of adenylate cyclase in human blood platelets by 9-substituted adenine derivatives. J.Cyclic Nucleotide Res. 5 125 PMID: 221552
Hourani et al (2001) Role of cyclic nucleotides in vasodilations of the rat thoracic aorta induced by adenosine analogues. Br.J.Pharmacol. 133 833 PMID: 11454656
Keywords: SQ 22536, supplier, Adenylyl, cyclase, inhibitors, inhibits, Cyclases, adenylate, SQ22536, Adenylyl, Cyclase, Adenylyl, Cyclase, Tocris Bioscience
