Biological Activity
Inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects in vivo. Does not activate transcription from the retinoic acid response element (RARE) and displays no activity at retinoic acid receptors (EC50 > 1 μM for RARα, RARβ, RARγ and RXRα).
Technical Data
| M. Wt | 376.54 |
| Formula | C26H32O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 160162-42-5 |
| PubChem ID | 9976842 |
| InChI Key | RQANARBNMTXCDM-DKOHIBGUSA-N |
| Smiles | CC(C=CC=C(C=CC1=C(C)CCCC1(C)C)C1=CC=C(C)C=C1)=C/C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.6 | 100 | |
| ethanol | 3.76 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 376.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.66 mL | 13.28 mL | 26.56 mL |
| 5 mM | 0.53 mL | 2.66 mL | 5.31 mL |
| 10 mM | 0.27 mL | 1.33 mL | 2.66 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
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References
References are publications that support the products' biological activity.
Shiohara et al (1999) Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic proliferation and differentiation in vitro. Blood 93 2057 PMID: 10068679
Huang et al (1997) Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid. Proc.Natl.Acad.Sci.USA 94 5826 PMID:
Fanjul et al (1994) A new class of retinoids with selective inhibition of AP-1 inhibits proliferation. Nature 372 107 PMID: 7969403
Keywords: SR 11302, supplier, inhibitors, inhibits, AP-1, transcription, factors, antitumor, agent, SR11302, AP-1, AP-1, Tocris Bioscience
