BiologicalActivity
Selectiveinverseagonistofretinoicacidreceptor-relatedorphanreceptorγ(RORγ)(Ki=105nM;IC50~320nM).ExhibitsweakactivityatliverXreceptorα(LXRα);doesnotaffectthetranscriptionalactivityoffarnesoidXreceptors(FXR),andhasnoimpactonthetranscriptionalactivityofRORα.
LicensingInformation
SoldunderlicensefromTheScrippsResearchInstitute.
CompoundLibraries
SR2211isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 527.48 |
| Formula | C26H24F7N3O |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1359164-11-6 |
| PubChemID | 51035449 |
| InChIKey | KVHKWAZUPPBMLL-UHFFFAOYSA-N |
| Smiles | FC(C=C(C(O)(C(F)(F)F)C(F)(F)F)C=C4)=C4C(C=C3)=CC=C3CN(CC2)CCN2CC1=CC=NC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 26.37 | 50 | |
| DMSO | 52.75 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight527.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.9mL | 9.48mL | 18.96mL |
| 5mM | 0.38mL | 1.9mL | 3.79mL |
| 10mM | 0.19mL | 0.95mL | 1.9mL |
| 50mM | 0.04mL | 0.19mL | 0.38mL |
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ProductDatasheets
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