BiologicalActivity
PotentCa2+channelantagoNIST;bindsallostericallytothea1-subunitofL-typeCa2+channels(Kd=20pM),atasitedistinctfromothertypesofblocker.Showssomeselectivityforvascularsmoothmuscle,inducingvasorelaxationwithoutproducinginotropicorchronotropiceffects.InhibitsPDGF-stimulatedsmoothmusclecellproliferation.
CompoundLibraries
SR33805oxalateisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 654.77 |
| Formula | C32H40N2O5S.C2H2O4 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 121346-33-6 |
| PubChemID | 21256218 |
| InChIKey | MZWPPDAHWIKZID-UHFFFAOYSA-N |
| Smiles | O=C(O)C(O)=O.O=S(C2=C(C(C)C)C1=CC=CC=C1N2C)(C3=CC=C(OCCCN(C)CCC4=CC=C(OC)C(OC)=C4)C=C3)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 56.47 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight654.77.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.53mL | 7.64mL | 15.27mL |
| 5mM | 0.31mL | 1.53mL | 3.05mL |
| 10mM | 0.15mL | 0.76mL | 1.53mL |
| 50mM | 0.03mL | 0.15mL | 0.31mL |
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