Biological Activity
A high affinity, selective 5-HT3 receptor agonist, active in vivo and CNS penetrant.
Technical Data
| M. Wt | 248.15 |
| Formula | C10H14ClN3.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 77145-61-0 |
| PubChem ID | 131746 |
| InChI Key | FUMINTAAUJUVMP-UHFFFAOYSA-N |
| Smiles | Cl.NC1CCN(CC1)C1=NC(Cl)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.82 | 100 | |
| water | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 248.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.03 mL | 20.15 mL | 40.3 mL |
| 5 mM | 0.81 mL | 4.03 mL | 8.06 mL |
| 10 mM | 0.4 mL | 2.01 mL | 4.03 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.81 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Bachy et al (1993) SR 57227A: a potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo. Eur.J.Pharmacol. 237 299 PMID: 7689975
Edwards et al (1996) 5-HT3-like receptors in the rat medial prefrontal cortex: further pharmacological characterization. Brain Res. 733 21 PMID: 8891244
Keywords: SR 57227 hydrochloride, supplier, Potent, selective, 5-HT3, agonists, Serotonin, Receptors, SR57227, hydrochloride, 5-HT3, Receptors, 5-HT3, Receptors, Tocris Bioscience
