Biological Activity
Potent and selective LIMK inhibitor (IC50 values are 43, 5536 and 6565 nM for LIMK1, ROCKI and ROCKII, respectively). Inhibits cofilin phosphorylation in A7r5 cells and suppresses migration and invasion of PC-3 cells in vitro. Orally bioavailable.
Technical Data
| M. Wt | 387.43 |
| Formula | C22H21N5O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1219728-20-7 |
| PubChem ID | 45381385 |
| InChI Key | WQAGVQVBDHOHRD-UHFFFAOYSA-N |
| Smiles | O=C(N(CCO)C4=CC=CC=C4)NC(C=C3)=CC=C3C1=C2C(NC=C2C)=NC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.74 | 100 | |
| ethanol | 3.87 | 10mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 387.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.58 mL | 12.91 mL | 25.81 mL |
| 5 mM | 0.52 mL | 2.58 mL | 5.16 mL |
| 10 mM | 0.26 mL | 1.29 mL | 2.58 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Yin et al (2015) Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors. J.Med.Chem. 58 1846 PMID: 25621531
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