Tocris/SSR 69071/2506/10/10毫克-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/SSR 69071/2506/10/10毫克

Tocris/SSR 69071/2506/10/10毫克

商品编号： 2506/10

品牌： Tocris Bioscience

市场价： ¥4100.00

美元价： 2460.00

产地：美国(厂家直采)

公司：

产品分类：蛋白酶类

公司分类： protease

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:Potent,orallyactivehumanleukocyteelastaseinhibitor

ChemicalName:2-[[6-Methoxy-4-(1-methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]-4H-pyrido[1,2-a]pyrimidin-4-one

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Highaffinity,potentinhibitorofhumanleukocyteelastase(HLE)(IC₅₀=3.9nM).Displaysspecies-selectivity(K_ivaluesare0.017,1.70,3.01,58and>100nM forhuman,mouse,rat,rabbitandporcineelastaserespectively).InhibitsHLE-inducedlunghemorrhageinmice(ID₅₀=2.8mg/kg)andreducesinfarctsizeinaninvivoacutemodelofcoronaryischemia-reperfusioninjury.Orallyactive.

TechnicalData

M.Wt	556.63
Formula	C₂₇H₃₂N₄O₇S
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	344930-95-6
PubChemID	9872438
InChIKey	DRZXDZYWZSKFDL-UHFFFAOYSA-N
Smiles	COC1=CC(C(C)C)=C2C(=O)N(COC3=CC(=O)N4C=CC=C(OCCN5CCCCC5)C4=N3)S(=O)(=O)C2=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	13.92	25
	ethanol	5.57	10

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight556.63.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.8mL	8.98mL	17.97mL
5mM	0.36mL	1.8mL	3.59mL
10mM	0.18mL	0.9mL	1.8mL
50mM	0.04mL	0.18mL	0.36mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

TechnicalData

SolubilityData

PreparingStockSolutions

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