Biological Activity
High affinity, selective agonist of 5-HT6 receptors (Ki values are 13, 168, and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors respectively). Displays moderate affinity for human α2 adrenergic receptors (Ki = 300 nM). Shown to increase Ca2+ concentration and phosphorylation of Fyn kinase, and regulate the activation of ERK1/2 in cloned cells.
Technical Data
| M. Wt | 326.78 |
| Formula | C13H17ClN2.C2H2O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1210-81-7 |
| PubChem ID | 90488934 |
| InChI Key | FHSPBPPTDFRVGQ-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(NC(C)=C2CCN(C)C)C2=C1.OC(C(O)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.68 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 326.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.06 mL | 15.3 mL | 30.6 mL |
| 5 mM | 0.61 mL | 3.06 mL | 6.12 mL |
| 10 mM | 0.31 mL | 1.53 mL | 3.06 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.61 mL |
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References
References are publications that support the products' biological activity.
Riccioni et al (2011) ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned 5-HT6 receptors. Eur.J.Pharmacol. 661 8 PMID: 21549693
Valentini et al (2011) A microdialysis study of ST1936, a novel 5-HT6 receptor agonist. Neuropharmacology 60 602 PMID: 21185318
Keywords: ST 1936 oxalate, supplier, ST1936, oxalate, selective, high, affinity, 5-ht6, agonists, 5-HT6, Receptors, 5-HT6, Receptors, Tocris Bioscience
