Biological Activity
NAMPT inhibitor (nicotinamide phosphoribosyltransferase, visfatin, PBEF1); inhibits NAD+ synthesis from nicotinamide. Potently inhibits the viability of multiple B-cell acute lymphoplastic leukemia (B-ALL) cell lines (IC50 < 10 nM); induces apoptosis in MF-411 cells. Induces regression of ALL xenografts and eliminates leukemia stems cells from bone marrow in mice.
Compound Libraries
STF 118804 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 461.53 |
| Formula | C25H23N3O4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 894187-61-2 |
| PubChem ID | 20916937 |
| InChI Key | DLFCEZOMHBPDGI-UHFFFAOYSA-N |
| Smiles | O=C(C2=CC=C(C3=NC(CS(C4=CC=C(C)C=C4)(=O)=O)=C(C)O3)C=C2)NCC1=CN=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.15 | 100 | |
| ethanol | 2.31 | 5mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 461.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.17 mL | 10.83 mL | 21.67 mL |
| 5 mM | 0.43 mL | 2.17 mL | 4.33 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.17 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Matheny et al (2013) Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem.Biol. 20 1352 PMID: 24183972
Keywords: STF 118804, supplier, STF118804, NAMPT, inhibitors, inhibits, potent, nicotinamide, phosphoribosyltransferase, visfatin, PBEF1, cytotoxic, Cancer, Stem, Cells, NAMPT, NAMPT, Tocris Bioscience
