Biological Activity
Selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki values are 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ respectively); competes for the ATP-binding site. Displays > 80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK.
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of STO-609 acetate is reviewed on the Chemical Probes website.
Technical Data
| M. Wt | 374.35 |
| Formula | C19H10N2O3.C2H4O2 |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1173022-21-3 |
| PubChem ID | 16760660 |
| InChI Key | WNRSTFUVBWNELX-UHFFFAOYSA-N |
| Smiles | CC(O)=O.OC(=O)C1=C2C=CC=C3C(=O)N4C5=CC=CC=C5N=C4C(C=C1)=C23 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 100mM NaOH | 16.85 | 45 | |
| DMSO | 3.74 | 10mM with sonication |
Preparing Stock Solutions
The following data is based on the product molecular weight 374.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.67 mL | 13.36 mL | 26.71 mL |
| 5 mM | 0.53 mL | 2.67 mL | 5.34 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.67 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Tokumitsu et al (2002) STO-609, a specific inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase. J.Biol.Chem. 277 15813 PMID: 11867640
Keywords: STO-609 acetate, supplier, Selective, CaM, kinases, inhibitors, inhibits, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, Calmodulin-Activated, Calcium, Binding, Protein, CaM, Kinase, Calcium, Binding, Protein, Tocris Bioscience
