Biological Activity
Selective inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 0.7 μM). Inhibits the protein-protein interaction between JNK and JIP (IC50 = 239 nM). Displays selectivity over p38 MAPK and Akt. Restores insulin sensitivity in a mouse model of type-2 diabetes.
Compound Libraries
SU 3327 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 261.3 |
| Formula | C5H3N5O2S3 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 40045-50-9 |
| PubChem ID | 11837140 |
| InChI Key | NQQBNZBOOHHVQP-UHFFFAOYSA-N |
| Smiles | NC2=NN=C(S2)SC1=NC=C([N+]([O-])=O)S1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.13 | 100 | |
| ethanol | 2.61 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 261.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.83 mL | 19.14 mL | 38.27 mL |
| 5 mM | 0.77 mL | 3.83 mL | 7.65 mL |
| 10 mM | 0.38 mL | 1.91 mL | 3.83 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.77 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
De et al (2009) Design, synthesis and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-jun N-terminal kinase. J.Med.Chem. 52 1943 PMID: 19271755
Keywords: SU 3327, supplier, SU3327, JNK, kinases, inhibitors, inhibits, selective, MAPK, Signaling, Signalling, c-Jun, N-Terminal, SAPKs, Stress-Activated, Protein, Mitogen-Activated, JNK/c-jun, JNK/c-jun, Tocris Bioscience
